Tensins – emerging insights into their domain functions, biological roles and disease relevance

ABSTRACT Tensins are a family of focal adhesion proteins consisting four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains activities contribute to the molecular linkage between extracellular matrix cytoskeletal networks, as well mediating signal transduction pathways, leading variety physiological processes, including cell proliferation, attachment, migration mechanical sensing cell. required for maintaining normal tissue structures functions, especially kidney heart, muscle regeneration, animals. This Review discusses our current understanding domain functions biological roles tensins cells mice, highlighting their relevance human diseases.